Hormonal Therapy for breast cancer and cardiac side effects

After surgery, women diagnosed with hormone-receptor-positive breast cancer usually take hormonal therapy medicine to reduce the risk of the cancer coming back (recurrence).

Types of Hormonal Therapy

Tamoxifen
    a selective estrogen receptor modulator (SERM)is used to treat both premenopausal and postmenopausal women.
  • may cause hot flashes
  • may increase the risk of endometrial cancer
  • may increase the risk of blood clots and stroke.

The aromatase inhibitors: 

  • Arimidex (anastrozole) 
  • Aromasin (exemestane) 
  • Femara (letrozole) 
    • more effective at reducing recurrence risk in postmenopausal women and are now used more often than tamoxifen to treat women who’ve gone through menopause.
    • not known to increase the risk of fatal heart attacks or strokes,
    • may trigger less serious heart side effects such as palpitation, arrhythmia , valve problems or pericarditis (inflammation of the heart surroundings, causing pain)
    • may cause muscle and joint aches and pains.
    • may trigger osteoporosis, and broken bones.

    How can we avoid cardiac side effects ?

    • Cardio Oncology discipline emerged to allow full cancer treatment without interruptions while taking precautions to avoid side effects
    • Individual evaluation by cardiology prior to starting cancer therapy will determine which treatment is right for you , avoiding cardiac side effects.
    • If minor cardiac side effects occur , we can treat them temporarily while you are on cancer therapy .
    • Your treatment plan isn’t written in stone. If another treatment has greater benefits and/or fewer side effects, you can always switch medications .
    • Cardiac adverse reactions are most of the time reversible if recognized early .
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